Research

We are developing microfluidic devices that deliver reagents to islets of Langerhans in complex temporal patterns to investigate how they respond. High speed separations with MS or optical detection are often employed. Example publications are:

1. Am. J. Physiol. Endocrinol. Metab, 2022 PDF
2. Analytical Chemistry, 2020  PDF
3. PLoS One, 2019  PDF 

We  develop analytical systems for monitoring release of small and large molecules from cells. High speed separations and spectroscopic methods help to detect these compounds. Example publications are:

1. Analytical and Bioanalytical Chemistry, 2023  PDF

2. Analytica Chimica Acta, 2022. PDF 

2. Analytical Methods, 2022  PDF

Microfluidic devices are ideal systems to automate various aspects of sample preparation.  We have  developed several devices that are being used to derivatize, stimulate, and collect from biological samples. Example publications are:

1. Analyst, 2023  PDF

2. Analytical Chemistry, 2018  PDF

The fabrication of glass microfluidic devices can be tricky, especially when attempting to make shallow channels.  Follow this link to a protocol that we have used with good success in making glass microfluidic chips.  This protocol has been published and should be  cited if used:

Baker, C. A.; Roper, M. G. “Continuous-flow, microchip electrophoresis fraction collector” Journal of Chromatography A 2010, 1217, 4743-4748.