We are developing microfluidic devices that deliver reagents to islets of Langerhans in complex temporal patterns to investigate how they respond. High speed separations with MS or optical detection are often employed. Example publications are:
We develop analytical systems for monitoring release of small and large molecules from cells. High speed separations and spectroscopic methods help to detect these compounds. Example publications are:
1. Analytical and Bioanalytical Chemistry, 2023 PDF
2. Analytica Chimica Acta, 2022. PDF
2. Analytical Methods, 2022 PDF
The fabrication of glass microfluidic devices can be tricky, especially when attempting to make shallow channels. Follow this link to a protocol that we have used with good success in making glass microfluidic chips. This protocol has been published and should be cited if used:
Baker, C. A.; Roper, M. G. “Continuous-flow, microchip electrophoresis fraction collector” Journal of Chromatography A 2010, 1217, 4743-4748.